Librería Servicio Médico

Author : Jerold Chun / Timothy Hla / Sarah Spiegel / Wouter Moolenaar

Language: English

Finishing : Hardcover, 812 pages

ISBN : 978-0-470-56905-4

Edition Number: 2013

Author Information:

JEROLD CHUN, MD, PhD, is a Professor at The Scripps Research Institute in La Jolla, California, and is a pioneer in the field of lysophospholipid signaling.

Description:

The current state of the science supporting new research in lysophospholipids

The study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports—ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems—have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling.

Lysophospholipid Receptors is divided into three sections:

• Receptors and other possible effectors
• Enzymes
• Physiology and pathophysiology

Within each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics.

Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field.

Table Of Contents:

• PREFACE ix
• CONTRIBUTORS xi
• 1 LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR SIGNALING 1
• Hope Mirendil, Mu-En Lin, and Jerold Chun
• 2 SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTORS 41
• Bongnam Jung and Timothy Hla
• 3 GLOBAL GENE EXPRESSION PROGRAM OF LYSOPHOSPHATIDIC ACID (LPA)-STIMULATED FIBROBLASTS 61
• Catelijne Stortelers and Wouter H. Moolenaar
• 4 IDENTIFICATION OF DIRECT INTRACELLULAR TARGETS OF SPHINGOSINE 1-PHOSPHATE (S1P) 71
• Nitai C. Hait, Sheldon Milstien, and Sarah Spiegel
• 5 LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS: THE RECEPTOR TYROSINE KINASE–G PROTEIN-COUPLED RECEPTOR SIGNALING COMPLEX 85
• Nigel J. Pyne and Susan Pyne
• 6 AUTOTAXIN: A UNIQUE ECTO-TYPE PYROPHOSPHODIESTERASE WITH DIVERSE FUNCTIONS 103
• Hiroshi Yukiura and Junken Aoki
• 7 STUDIES ON AUTOTAXIN SIGNALING IN ENDOCYTIC VESICLE BIOGENESIS AND EMBRYONIC DEVELOPMENT USING WHOLE EMBRYO CULTURE AND ELECTROPORATION 121
• Masayuki Masu, Seiichi Koike, Takuya Okada, and Kazuko Keino-Masu
• 8 STANDARDIZATION AND QUANTIFICATION OF LYSOPHOSPHATIDIC ACID COMPOUNDS BY NORMAL-PHASE AND REVERSED-PHASE CHROMATOGRAPHY–TANDEM MASS SPECTROMETRY 137
• Jeff D. Moore, Shengrong Li, David S. Myers, Stephen B. Milne, H. Alex Brown, and Walter A. Shaw
• 9 SPHINGOSINE KINASES: BIOCHEMISTRY, REGULATION, AND ROLES 153
• Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham, and Stuart M. Pitson
• 10 FUNCTIONAL AND PHYSIOLOGICAL ROLES OF SPHINGOSINE 1-PHOSPHATE TRANSPORTERS 185
• Atsuo Kawahara and Tsuyoshi Nishi
• 11 LIPID PHOSPHATE PHOSPHATASES AND SIGNALING BY LYSOPHOSPHOLIPID RECEPTORS 201
• Ganesh Venkatraman and David N. Brindley
• 12 LIPID PHOSPHATE PHOSPHATASES: RECENT PROGRESS AND ASSAY METHODS 229
• Andrew J. Morris, Susan S. Smyth, Abdel K. Salous, and Andrew D. Renault
• 13 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND CARDIOVASCULAR PATHOLOGY 265
• Susan S. Smyth, Anping Dong, Jessica Wheeler, Manikandan Panchatcharam, and Andrew J. Morris
• 14 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING IN CARDIOVASCULAR PHYSIOLOGY AND DISEASE 283
• Bodo Levkau
• 15 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND THE VASCULATURE 313
• Christian Waeber
• 16 REGULATION OF THE NUCLEAR HORMONE RECEPTOR PPARγ BY ENDOGENOUS LYSOPHOSPHATIDIC ACIDS (LPAS) 349
• Ryoko Tsukahara, Tamotsu Tsukahara, and Gabor Tigyi
• 17 MECHANISMS AND MODELS FOR ELUCIDATING THE CARDIAC EFFECTS OF SPHINGOSINE 1-PHOSPHATE (S1P) 373
• Shigeki Miyamoto, Sunny Yang Xiang, Nicole H. Purcell, and Joan Heller Brown
• 18 NEURAL EFFECTS OF LYSOPHOSPHATIDIC ACID (LPA) SIGNALING 399
• Nobuyuki Fukushima
• 19 WIDESPREAD EXPRESSION OF SPHINGOSINE KINASES AND SPHINGOSINE 1-PHOSPHATE (S1P) LYASE SUGGESTS DIVERSE FUNCTIONS IN THE VERTEBRATE NERVOUS SYSTEM 419
• H. Meng and V.M. Lee
• 20 LYSOPHOSPHATIDIC ACID AND NEUROPATHIC PAIN: DEMYELINATION AND LPA BIOSYNTHESIS 433
• Hiroshi Ueda
• 21 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN BEHAVIORAL PROCESSES: IMPLICATIONS FOR PSYCHIATRIC DISORDERS 451
• Guillermo Estivill-Torrús, Luis Javier Santín, Carmen Pedraza, Estela Castilla-Ortega, and Fernando Rodríguez de Fonseca
• 22 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND LYMPHOCYTE EGRESS 475
• Alejandra Mendoza, Lauren A. Pitt, and Susan R. Schwab
• 23 BIOLOGY REVEALED BY SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR GENE-ALTERED MICE 489
• Maria L. Allende, Mari Kono, Aikaterini Alexaki, Christina Giannouli, Jiman Kang, Catherine C. Theisen, Eleanor L. Koerner, and Richard L. Proia
• 24 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN THE INTESTINE 507
• C. Chris Yun and Peijian He
• 25 LYSOPHOSPHOLIPID SIGNALING IN FEMALE AND MALE REPRODUCTIVE SYSTEMS 529
• Xiaoqin Ye
• 26 THE GONADS AND THEIR MAGIC BULLET, LYSOPHOSPHATIDIC ACID: PHYSIOLOGICAL AND TOXICOLOGICAL FUNCTIONS OF LYSOPHOSPHATIDIC ACID (LPA) IN FEMALE AND MALE REPRODUCTIVE SYSTEMS 569
• Lygia Therese Budnik, Bärbel Brunswig-Spickenheier, and Dieter Müller
• 27 LYSOPHOSPHOLIPID REGULATION OF LUNG FIBROSIS 587
• Barry S. Shea and Andrew M. Tager
• 28 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE 609
• Jean Pierre Salles, Sara Laurencin-Dalicieux, Françoise Conte-Auriol, Fabienne Briand-Mésange, and Isabelle Gennero
• 29 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE CANCER 627
• Olivier Peyruchaud, Marion David, Timothy L. Macdonald, and Kevin R. Lynch
• 30 UNDERSTANDING THE FUNCTIONS OF LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER 641
• Nattapon Panupinthu and Gordon B. Mills
• 31 LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER 661
• Abir Mukherjee, Jinhua Wu, Yongling Gong, and Xianjun Fang
• 32 LPA RECEPTOR SUBTYPES LPA1 AND LPA2 AS POTENTIAL DRUG TARGETS 681
• Gretchen Bain and T. Jon Seiders
• 33 CLINICAL INTRODUCTION OF LYSOPHOSPHATIDIC ACID (LPA) AND AUTOTAXIN ASSAYS 709
• Yutaka Yatomi, Koji Igarashi, Kazuhiro Nakamura, Ryunosuke Ohkawa, Akiko Masuda, Akiko Suzuki, Tatsuya Kishimoto, Hitoshi Ikeda, and Junken Aoki
• 34 ANTIBODIES TO BIOACTIVE LYSOPHOSPHOLIPIDS 737
• Roger A. Sabbadini, Jonathan M. Wojciak, Kelli Moreno, James S. Swaney, and Barbara Visentin
• INDEX 753

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